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Symptoms: Frequent itchy skin with mostly pale wheals of different sizes and arrangements. 

18+

Age: 18+

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Treatment: 12 weeks

Do you suffer from itchy wheals and redness on your skin when you come in contact with cold air, cold liquids or cold objects? Or do these wheals occur as a result of scratching, rubbing or scrubbing?
We are looking for patients aged 18+ with cold contact urticaria (also called cold allergy) and for patients with symptomatic dermographism.

Contact us

STUDY PHASE: I

This study will be performed to evaluate the safety profile of a single dose of CDX-0159 in patient with cold contact urticaria and symptomatic dermographism who remain symptomatic despite treatment with antihistamines.

Symptoms: 

Frequent itchy skin with mostly pale wheals of different sizes and arrangements. 

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Treatment and Study duration: 

Intravenous infusion on the day of treatment; follow-up visits  

Maximum study duration per patient: 12 weeks  

What is cold contact urticaria?

Within minutes after cold contact wheals appear on the skin. The triggering form of cold (whether air, water, cold objects, cold drinks or meals, body temperature, evaporating sweat) is individually very different. The symptoms on the skin appear where the cold acts, which is why the unclothed body regions such as hands and face are mostly affected.

What is symptomatic dermographism? 

It is a skin reaction where itchy wheals appear as a direct result of scratching, rubbing, or scrubbing. The skin around the wheal is more or less red. The wheals will occur only at the irritation area and do not expand any further. 

We are looking for participants with the diagnosis cold contact urticaria or symptomatic dermographism for our clinical. We will help you to get a better understanding of your condition and possible treatment options.  

 You will receive free study-related treatment from our specialists and a reimbursement of your travel expenses. 

 If interested in a study participation, please contact us. 

Who can participate in this study? 

Male and female patients between 18 and 75 years of age. 

  • With the diagnosis of cold contact urticaria and symptomatic dermographism who remain symptomatic despite treatment with antihistamines 

 

Who cannot participate in this study? 

  • Patients with wheals or angioedema other than chronic urticaria 
  • Patients that received a prior biologic therapy (e.g. Omalizumab, DupilumabLigelizumab) within past 3 months 
  • Patients that received a treatment with immunosuppressives (e.g. systemic corticosteroids, Cyclosporine, Methotrexate, etc.) within 4 weeks  
  • Patients with active Covid-19 infection 
  • Participation in another research study involving an investigational product in the past 4 weeks  
  • Current oplanned pregnancy or nursing women  

Contact us

Address:

Charité-Universitätsmedizin Berlin, AG Maurer, MAD³-Sprechstunde, Klinik für Dermatologie, Allergologieund Venerologie, Charitéplatz 1, 10117 Berlin

Phone:

+49 30 450 518 623

E-Mail:

Mad-sprechstunde@charite.de