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Symptoms: Frequent itchy skin with mostly pale wheals of different sizes and arrangements. 


Age: 18+

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Treatment: 12 weeks

Do you suffer from itchy wheals and redness on your skin when you come in contact with cold air, cold liquids or cold objects? Or do these wheals occur as a result of physical exertion, sweating or a full bath? These symptoms can also be caused by scratching, rubbing or scrubbing.
We are looking for patients aged 18+ with cold contact urticaria (also called cold allergy) or cholinergic urticaria (also called sweat urticaria).

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This study will be performed to evaluate the safety profile of a single dose of CDX-0159 in patient with cold contact urticaria and cholinergic urticaria who remain symptomatic despite treatment with antihistamines.


Frequent itchy skin with mostly pale wheals of different sizes and arrangements. 

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Treatment and Study duration: 

Intravenous infusion on the day of treatment; follow-up visits  

Maximum study duration per patient: 12 weeks  

What is cold contact urticaria?

Within minutes after cold contact wheals appear on the skin. The triggering form of cold (whether air, water, cold objects, cold drinks or meals, body temperature, evaporating sweat) is individually very different. The symptoms on the skin appear where the cold acts, which is why the unclothed body regions such as hands and face are mostly affected.

What is cholinergic urticaria?

In cholinergic urticaria, wheals and itching occur. Physical exertion during sports, hot climates, a hot bath or emotional stress can be triggers. Redness and small wheals about the size of a pinhead on the whole body are typical.

We are looking for participants with the diagnosis cold contact urticaria or cholinergic urticaria for our clinical trial. We will help you to get a better understanding of your condition and possible treatment options.  

 You will receive free study-related treatment from our specialists and a reimbursement of your travel expenses. 

 If interested in a study participation, please contact us. 

Who can participate in this study? 

Male and female patients between 18 and 75 years of age. 

  • With the diagnosis of cold contact urticaria or cholinergic urticaria who remain symptomatic despite treatment with antihistamines 


Who cannot participate in this study? 

  • Patients with wheals or angioedema other than chronic urticaria 
  • Patients that received a prior biologic therapy (e.g. DupilumabLigelizumab) within past 3 months 
  • Patients that received a treatment with immunosuppressives (e.g. systemic corticosteroids, Cyclosporine, etc.) within 4 weeks  
  • Patients with active Covid-19 infection 
  • Participation in another research study involving an investigational product in the past 4 weeks  
  • Current oplanned pregnancy or nursing women  

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Charité-Universitätsmedizin Berlin, AG Maurer, MAD³-Sprechstunde, Klinik für Dermatologie, Allergologieund Venerologie, Charitéplatz 1, 10117 Berlin


+49 30 450 518 623